Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 4th International Conference on Polymer Chemistry Stockholm, Sweden.

Day 2 :

OMICS International Euro Polymer Chemistry 2018 International Conference Keynote Speaker Oomen P Oommen photo
Biography:

Oommen P Oommen has received his PhD in Organic Chemistry from Indian Institute of Technology, Bombay. He then moved to Uppsala University, Sweden to pursue his Post-Doctoral studies. In 2016, he joined Tampere University of Technology, Finland as an Assistant Professor where he leads a multidisciplinary team of chemists, molecular biologists and material scientists. His research interests are in the fields of designing functional polymers and biomaterials for tissue engineering, drug delivery and nucleic acid therapeutics. He authored several peer reviewed articles and book chapters. He has also filed several patents and is a Co-founder of a spin-off called ‘Uppsala Therapeutics AB’

Abstract:

Glycoaminoglycans, such as hyaluronic acid (HA) and chondroitin sulfate (CS), are natural biopolymers present in the extracellular matrix (ECM) that have generated great interest for designing drug delivery systems. As HA and CS possess a unique ability to target CD44 receptors that are overexpressed in malignant solid tumors (nearly 6-8 folds higher than normal tissues), they have been used for anticancer therapeutics. Moreover, hyaluronidase, a ubiquitious enzyme that degrade these polymers are expressed highly in these malignant tumors, resulting in rapid turnover of these polymers in tumor tissue. We have recently engineered HA and CS derived soft nanocarriers and compared their tumor targeting properties and evaluated their role in the activation of complement and coagulation cascade reactions in human blood. We found that CS undergoes faster cellular uptake properties than HA. CS being a sulfated polymer, unlike HA, demonstrated activation of complement at higher concentrations. Thereafter, we engineered CS coated gold nanoparticles following a green chemistry strategy. Doxorubicin (DOX) a clinically used antineoplastic agent was conjugated to the CS-gold nanoparticle (CS-Au-DOX) via pH-responsive hydrazone linkages, which yielded sustained drug release profile at acidic pH. Unlike other colloidal gold particles, CS-AuDOX was extremely stable and could be stored as a lyophilized powder. The CS-Au-DOX exhibited higher toxicity towards CD44 overexpressing human colon cancer cells (HCT116 and GP5D) as compared to free DOX. Interestingly, CS-Au-DOX also overcame multidrug resistance induced by p-glycoprotein overexpression in ovarian cancer cell line A2780. The confocal laser scanning microscopy images clearly showed nuclear transport of these DOX loaded nanoparticles. We incubated free DOX and CS-Au-DOX with non-anticoagulated human whole blood to estimate the thromboinflammation and platelet aggregation. We observed that doxorubicin (DOX) induced acute platelet toxicity and trigger coagulation cascade in human whole blood model. CS-Au-DOX on the other hand mitigated DOX mediated toxicity to human platelets and suppressed thromboinflammation. Our studies reveal that GAG derived nanoparticles offer new avenues to design innocuous drug delivery system that could mitigate drug mediated side effects.
 

Keynote Forum

Sang Youl Kim

Korea Advanced Institute of Science and Technology, Korea

Keynote: Synthesis of polyamidoamine hydrogel particles for environmental applications

Time : 10:15-11:00

OMICS International Euro Polymer Chemistry 2018 International Conference Keynote Speaker Sang Youl  Kim photo
Biography:

Sang Youl Kim is a Tenured Full Professor of Chemistry Department at KAIST. He has obtained his Master’s degree at KAIST and his PhD at Rensselaer Polytechnic Institute. He did his Post-doctoral work at IBM Almaden Research Center, and then joined R&D of LG Chemicals. After three years of industrial research at LG, he has moved to KAIST in 1994. He served as the Department Head and as a Chairman of the Association of KAIST Professors. His research interests include new polymerization reactions and methods, polymeric materials with controlled architecture, design and synthesis of functional macromolecules, and selfassembled organic materials.

Abstract:

Highly branched structures with a large number of functional groups of poly(amidoamine) (PAMAM) dendrimers and hyperbranched polymers make these materials very useful in many applications including host-guest encapsulation, nanoreactors, and delivery devices. We used both the advantages and limitations of A2+B4 polycondensation method to make hyperbranched PAMAM hydrogel particles. Aqueous solution of hyperbranched PAMAM precursors was prepared by slow addition of A2 monomer, N,N’-methylenebisacrylamide, to aqueous solution of B4 monomer, ethylenediamine. And then the aqueous solution of hyperbranched PAMAM precursor was dispersed in a hydrophobic liquid and the A2+B4 polycondensation proceeded until the critical gelation point. This simple method allowed us to make micro-sized hydrogel particles which wholly consisted of hyperbranched poly(amidoamine). The hyperbranched PAMAM hydrogel particles were found to be highly effective for the capturing of heavy metal ions from an aqueous solution and CO2.
 

Keynote Forum

Ayan Samanta

Uppsala University, Sweden

Keynote: Biomedical Applications of ECM derived polymers

Time : 11:15-12:00

OMICS International Euro Polymer Chemistry 2018 International Conference Keynote Speaker Ayan Samanta photo
Biography:

Dr Ayan Samanta has completed his PhD from Heidelberg University, Germany in 2012. His doctoral work was focused on different aspects of nucleic acid chemistry. After several years of postdoctoral training in Heidelberg University, the University of Tübingen, and Linköping University, he has moved to Uppsala University where he currently holds a Senior Researcher and Principal Investigator position. His team employs chemical tools to solve biological and medical problems. The main research focus of his lab is biomaterial-induced corneal and cardiac regeneration. Currently, the lab also focuses on the green synthesis of polymers.

 

Abstract:

Extracellular matrix (ECM) derived polymers have proven to be extremely useful in preparing scaffolds for tissue regeneration in vivo. Hydrogels manufactured from such polymers have the advantage of having high compatibility with cells in vitro and in vivo. Moreover, such polymers are entirely degraded inside the body and therefore, can be used for long-term in vivo applications. Collagen is the most abundant component in ECM, and therefore, collagen-based biomaterials have gained enormous importance in regenerative medicine in recent years. We have developed collagen-based, acellular biomaterials which can be used as an alternative to donor cornea transplantation and can promote regeneration of a damaged cornea. Hence, the need for donor organs, which are always under shortage, can be minimised. Since our approach is cell-free, it facilitates the regulatory acceptance. We have established the usefulness of our strategy by treating corneal blindness in animal model and limited clinical trials in patients. A major drawback of the currently developed corneal implants is their poor mechanical strength and the need to use the full-length protein such as collagen which is difficult to handle. Hence, our current approach includes the use of synthetic degradable polymers to fabricate tough hydrogels with molecular elements of stress distribution and energy dissipation. Such tough hydrogels can be handled as easily as a donor cornea and therefore, will potentiate the widespread use of this technique. Towards the end, we will also demonstrate the application of our acellular biomaterials for cardiac regeneration.