Day 2 :
Tampere University of Technology, Finland
Keynote: Glycosaminoglycan derived nanocarriers: Exploiting natural biopolymers for tumor targeting and mitigating immune activation
Time : 09:30-10:15
Oommen P Oommen has received his PhD in Organic Chemistry from Indian Institute of Technology, Bombay. He then moved to Uppsala University, Sweden to pursue his Post-Doctoral studies. In 2016, he joined Tampere University of Technology, Finland as an Assistant Professor where he leads a multidisciplinary team of chemists, molecular biologists and material scientists. His research interests are in the fields of designing functional polymers and biomaterials for tissue engineering, drug delivery and nucleic acid therapeutics. He authored several peer reviewed articles and book chapters. He has also filed several patents and is a Co-founder of a spin-off called ‘Uppsala Therapeutics AB’
Korea Advanced Institute of Science and Technology, Korea
Time : 10:15-11:00
Sang Youl Kim is a Tenured Full Professor of Chemistry Department at KAIST. He has obtained his Master’s degree at KAIST and his PhD at Rensselaer Polytechnic Institute. He did his Post-doctoral work at IBM Almaden Research Center, and then joined R&D of LG Chemicals. After three years of industrial research at LG, he has moved to KAIST in 1994. He served as the Department Head and as a Chairman of the Association of KAIST Professors. His research interests include new polymerization reactions and methods, polymeric materials with controlled architecture, design and synthesis of functional macromolecules, and selfassembled organic materials.
Uppsala University, Sweden
Time : 11:15-12:00
Dr Ayan Samanta has completed his PhD from Heidelberg University, Germany in 2012. His doctoral work was focused on different aspects of nucleic acid chemistry. After several years of postdoctoral training in Heidelberg University, the University of Tübingen, and Linköping University, he has moved to Uppsala University where he currently holds a Senior Researcher and Principal Investigator position. His team employs chemical tools to solve biological and medical problems. The main research focus of his lab is biomaterial-induced corneal and cardiac regeneration. Currently, the lab also focuses on the green synthesis of polymers.
Extracellular matrix (ECM) derived polymers have proven to be extremely useful in preparing scaffolds for tissue regeneration in vivo. Hydrogels manufactured from such polymers have the advantage of having high compatibility with cells in vitro and in vivo. Moreover, such polymers are entirely degraded inside the body and therefore, can be used for long-term in vivo applications. Collagen is the most abundant component in ECM, and therefore, collagen-based biomaterials have gained enormous importance in regenerative medicine in recent years. We have developed collagen-based, acellular biomaterials which can be used as an alternative to donor cornea transplantation and can promote regeneration of a damaged cornea. Hence, the need for donor organs, which are always under shortage, can be minimised. Since our approach is cell-free, it facilitates the regulatory acceptance. We have established the usefulness of our strategy by treating corneal blindness in animal model and limited clinical trials in patients. A major drawback of the currently developed corneal implants is their poor mechanical strength and the need to use the full-length protein such as collagen which is difficult to handle. Hence, our current approach includes the use of synthetic degradable polymers to fabricate tough hydrogels with molecular elements of stress distribution and energy dissipation. Such tough hydrogels can be handled as easily as a donor cornea and therefore, will potentiate the widespread use of this technique. Towards the end, we will also demonstrate the application of our acellular biomaterials for cardiac regeneration.
- Polymer Engineering and Technology|Nanopolymers and Nanotechnology|Future Scope of Polymer Science|Biodgradable Polymers
Kocaeli University, Turkey
Title: Synthesis of diosgenin containing m-PEG-PCL nanoparticles: Anticancer, antimicrobial and drug delivery studies
Time : 15:30-16:05
Sevinc Ilkar Erdagi is pursuing her PhD in Kocaeli University, Turkey under supervision of Prof. Dr. Ufuk Yildiz. She is a Research Assistant in Kocaeli University for seven years. She studies Organic Chemistry and Polymer Chemistry especially in steroid chemistry and natural products.
Diosgenin is a steroidal saponin from a therapeutic herb. Natural products have always played a highly significant and potential role in the drug discovery. Here, we developed a nanoparticle platform based on poly(ethylene glycol)poly(caprolactone)–diosgenin (mPEG-PCL–DGN) conjugates for co-delivery of anticancer drugs. Firstly, to improve the solubility and bioavailability of DGN, the amphiphilic conjugates mPEG-PCL-DGN were made by linking DGN with PCL and mPEG. Then they self-assembled nanoparticles to deliver another anticancer drug imatinib mesylate (ITB) by a simple nanoprecipitation method. The obtained nanoparticles possessed the appropriate size, high drug loading efficiency of diosgenin and ITB. In this study, polymer–drug conjugates mPEG–PCLDGN was synthesized based on PCL, mPEG, and diosgenin, in which diosgenin, PCL and mPEG were used as the hydrophobic and the hydrophilic segment, respectively. Then the mPEG– DGN self-assembled into a polymeric nanoparticle with linear PCL, mPEG, and diosgenin (Figure). The nanoparticles were developed as an important strategy for drug delivery due to their capabilities of enhancing drug solubility
Aurel Vlaicu University of Arad, Romania
Time : 13:45-14:20
Kumoh National Institute of Technology, Korea
Time : 14:20-14:55
Byung Gil Min has completed his PhD from Seoul National University and Post-doctoral studies from IBM Almaden Research Center in California, USA. He is a Professor of Kumoh National Institute of Technology located at Gumi in South Korea.
University of New Mexico, USA
Time : 14:55-15:30