Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 4th International Conference on Polymer Chemistry Stockholm, Sweden.

Day 2 :

Conference Series Euro Polymer Chemistry 2018 International Conference Keynote Speaker Oomen P Oommen photo
Biography:

Oommen P Oommen has received his PhD in Organic Chemistry from Indian Institute of Technology, Bombay. He then moved to Uppsala University, Sweden to pursue his Post-Doctoral studies. In 2016, he joined Tampere University of Technology, Finland as an Assistant Professor where he leads a multidisciplinary team of chemists, molecular biologists and material scientists. His research interests are in the fields of designing functional polymers and biomaterials for tissue engineering, drug delivery and nucleic acid therapeutics. He authored several peer reviewed articles and book chapters. He has also filed several patents and is a Co-founder of a spin-off called ‘Uppsala Therapeutics AB’

Abstract:

Glycoaminoglycans, such as hyaluronic acid (HA) and chondroitin sulfate (CS), are natural biopolymers present in the extracellular matrix (ECM) that have generated great interest for designing drug delivery systems. As HA and CS possess a unique ability to target CD44 receptors that are overexpressed in malignant solid tumors (nearly 6-8 folds higher than normal tissues), they have been used for anticancer therapeutics. Moreover, hyaluronidase, a ubiquitious enzyme that degrade these polymers are expressed highly in these malignant tumors, resulting in rapid turnover of these polymers in tumor tissue. We have recently engineered HA and CS derived soft nanocarriers and compared their tumor targeting properties and evaluated their role in the activation of complement and coagulation cascade reactions in human blood. We found that CS undergoes faster cellular uptake properties than HA. CS being a sulfated polymer, unlike HA, demonstrated activation of complement at higher concentrations. Thereafter, we engineered CS coated gold nanoparticles following a green chemistry strategy. Doxorubicin (DOX) a clinically used antineoplastic agent was conjugated to the CS-gold nanoparticle (CS-Au-DOX) via pH-responsive hydrazone linkages, which yielded sustained drug release profile at acidic pH. Unlike other colloidal gold particles, CS-AuDOX was extremely stable and could be stored as a lyophilized powder. The CS-Au-DOX exhibited higher toxicity towards CD44 overexpressing human colon cancer cells (HCT116 and GP5D) as compared to free DOX. Interestingly, CS-Au-DOX also overcame multidrug resistance induced by p-glycoprotein overexpression in ovarian cancer cell line A2780. The confocal laser scanning microscopy images clearly showed nuclear transport of these DOX loaded nanoparticles. We incubated free DOX and CS-Au-DOX with non-anticoagulated human whole blood to estimate the thromboinflammation and platelet aggregation. We observed that doxorubicin (DOX) induced acute platelet toxicity and trigger coagulation cascade in human whole blood model. CS-Au-DOX on the other hand mitigated DOX mediated toxicity to human platelets and suppressed thromboinflammation. Our studies reveal that GAG derived nanoparticles offer new avenues to design innocuous drug delivery system that could mitigate drug mediated side effects.
 

Keynote Forum

Sang Youl Kim

Korea Advanced Institute of Science and Technology, Korea

Keynote: Synthesis of polyamidoamine hydrogel particles for environmental applications

Time : 10:15-11:00

Conference Series Euro Polymer Chemistry 2018 International Conference Keynote Speaker Sang Youl  Kim photo
Biography:

Sang Youl Kim is a Tenured Full Professor of Chemistry Department at KAIST. He has obtained his Master’s degree at KAIST and his PhD at Rensselaer Polytechnic Institute. He did his Post-doctoral work at IBM Almaden Research Center, and then joined R&D of LG Chemicals. After three years of industrial research at LG, he has moved to KAIST in 1994. He served as the Department Head and as a Chairman of the Association of KAIST Professors. His research interests include new polymerization reactions and methods, polymeric materials with controlled architecture, design and synthesis of functional macromolecules, and selfassembled organic materials.

Abstract:

Highly branched structures with a large number of functional groups of poly(amidoamine) (PAMAM) dendrimers and hyperbranched polymers make these materials very useful in many applications including host-guest encapsulation, nanoreactors, and delivery devices. We used both the advantages and limitations of A2+B4 polycondensation method to make hyperbranched PAMAM hydrogel particles. Aqueous solution of hyperbranched PAMAM precursors was prepared by slow addition of A2 monomer, N,N’-methylenebisacrylamide, to aqueous solution of B4 monomer, ethylenediamine. And then the aqueous solution of hyperbranched PAMAM precursor was dispersed in a hydrophobic liquid and the A2+B4 polycondensation proceeded until the critical gelation point. This simple method allowed us to make micro-sized hydrogel particles which wholly consisted of hyperbranched poly(amidoamine). The hyperbranched PAMAM hydrogel particles were found to be highly effective for the capturing of heavy metal ions from an aqueous solution and CO2.
 

Keynote Forum

Ayan Samanta

Uppsala University, Sweden

Keynote: Biomedical Applications of ECM derived polymers

Time : 11:15-12:00

Conference Series Euro Polymer Chemistry 2018 International Conference Keynote Speaker Ayan Samanta photo
Biography:

Dr Ayan Samanta has completed his PhD from Heidelberg University, Germany in 2012. His doctoral work was focused on different aspects of nucleic acid chemistry. After several years of postdoctoral training in Heidelberg University, the University of Tübingen, and Linköping University, he has moved to Uppsala University where he currently holds a Senior Researcher and Principal Investigator position. His team employs chemical tools to solve biological and medical problems. The main research focus of his lab is biomaterial-induced corneal and cardiac regeneration. Currently, the lab also focuses on the green synthesis of polymers.

 

Abstract:

Extracellular matrix (ECM) derived polymers have proven to be extremely useful in preparing scaffolds for tissue regeneration in vivo. Hydrogels manufactured from such polymers have the advantage of having high compatibility with cells in vitro and in vivo. Moreover, such polymers are entirely degraded inside the body and therefore, can be used for long-term in vivo applications. Collagen is the most abundant component in ECM, and therefore, collagen-based biomaterials have gained enormous importance in regenerative medicine in recent years. We have developed collagen-based, acellular biomaterials which can be used as an alternative to donor cornea transplantation and can promote regeneration of a damaged cornea. Hence, the need for donor organs, which are always under shortage, can be minimised. Since our approach is cell-free, it facilitates the regulatory acceptance. We have established the usefulness of our strategy by treating corneal blindness in animal model and limited clinical trials in patients. A major drawback of the currently developed corneal implants is their poor mechanical strength and the need to use the full-length protein such as collagen which is difficult to handle. Hence, our current approach includes the use of synthetic degradable polymers to fabricate tough hydrogels with molecular elements of stress distribution and energy dissipation. Such tough hydrogels can be handled as easily as a donor cornea and therefore, will potentiate the widespread use of this technique. Towards the end, we will also demonstrate the application of our acellular biomaterials for cardiac regeneration.

 

 

  • Polymer Engineering and Technology|Nanopolymers and Nanotechnology|Future Scope of Polymer Science|Biodgradable Polymers
Speaker
Biography:

Sevinc Ilkar Erdagi is pursuing her PhD in Kocaeli University, Turkey under supervision of Prof. Dr. Ufuk Yildiz. She is a Research Assistant in Kocaeli University for seven years. She studies Organic Chemistry and Polymer Chemistry especially in steroid chemistry and natural products.

Abstract:

Diosgenin is a steroidal saponin from a therapeutic herb. Natural products have always played a highly significant and potential role in the drug discovery. Here, we developed a nanoparticle platform based on poly(ethylene glycol)poly(caprolactone)–diosgenin (mPEG-PCL–DGN) conjugates for co-delivery of anticancer drugs. Firstly, to improve the solubility and bioavailability of DGN, the amphiphilic conjugates mPEG-PCL-DGN were made by linking DGN with PCL and mPEG. Then they self-assembled nanoparticles to deliver another anticancer drug imatinib mesylate (ITB) by a simple nanoprecipitation method. The obtained nanoparticles possessed the appropriate size, high drug loading efficiency of diosgenin and ITB. In this study, polymer–drug conjugates mPEG–PCLDGN was synthesized based on PCL, mPEG, and diosgenin, in which diosgenin, PCL and mPEG were used as the hydrophobic and the hydrophilic segment, respectively. Then the mPEG– DGN self-assembled into a polymeric nanoparticle with linear PCL, mPEG, and diosgenin (Figure). The nanoparticles were developed as an important strategy for drug delivery due to their capabilities of enhancing drug solubility

Fogorasi Magdalena Simona

Aurel Vlaicu University of Arad, Romania

Title: Biotechnology – Tool for modification of polymers for textile application

Time : 13:45-14:20

Speaker
Biography:

Fogorasi Magdalena Simona is working as an Associate Professor at the Aurel Vlaicu University of Arad, Romania with expertise in Textile Chemistry. She has accomplished her PhD in the field of Textile Biotechnology. She has collaborated on several European and National projects on Textile Finishing, particularly on Biotechnology for fibers modification and textile waste valorization. She is a reviewer for several prominent journals and Editorial Board Member. Her research interests are textile biotechnology, enzyme immobilization, textile fibers and polymers, dyestuff and surfactants and environmental protection.
 

Abstract:

Polymers are present in almost every aspect of our daily life. Textile field is one of the largest industry using fibers derived from both natural and synthetic polymers. In the last decades, the textile industry has endorsed significant growth in new fibers, especially synthetic fibers with improved and special properties, most of them designed for niche products. For this century, the new fibers will be created in association with other industrial fields, being notably influenced by the information technology and advances in nano- and biotechnology. Application of biotechnology to polymer/textile materials envisages emerging areas like improvement and adjustment of properties in fibers and development of new fibers and polymers. The presentation is addressed to the potential of biotechnology to improve and modify properties in polymers, with special reference to biochemical processing of fibers acquired from natural polymers. The benefits of biotechnologies - as convenient alternatives to traditional chemical procedures - are exploited in processing of natural and synthetic polymers. Natural fibers like cotton and wool possess a non-even and nonhomogeneous surface. Their specific function can be ascribed to their complicated morphological structure. Conventionally, raw fibers are subjected to several chemical processes to obtain desired features proper for use. The paper offers an authentic approach in highlighting the interface between biotechnology and polymers (textile fibers) dealing with reaction mechanisms, modified fibers properties and environmental issues.
 

Byung Gil Min

Kumoh National Institute of Technology, Korea

Title: Preparation of superhydrophobic and antibacterial fabrics through biomimetic lotus effect

Time : 14:20-14:55

Speaker
Biography:

Byung Gil Min has completed his PhD from Seoul National University and Post-doctoral studies from IBM Almaden Research Center in California, USA. He is a Professor of Kumoh National Institute of Technology located at Gumi in South Korea.

Abstract:

Superhyrodrophobic textiles were prepared through a biomimetic method of the lotus effect. It has been known that physical roughness and chemical hydrophobicity were essential to attain the lotus effect on textiles. Two different routes were applied for reproducing lotus effect on textiles. Firstly, physical roughness was controlled by adopting silica nanoparticles on the surface of textiles as well as chemical hydrophobicity was added by treating the surfaces with a commercial water-repellent agent. Narrow-size distributed silica nanoparticles were prepared by a sol-gel process. The water contact angle of the textiles treated with both silica nanoparticles and water-repellent agent reached up to 158°, which was much higher than 137° reached by the water-repellent agent only. For the immobilization of silica nano-particles and hydrophobic surface, a novel one-step process was investigated by synthesizing silica particles having hydrophobic vinyl groups and immobilization the silica with as UV irradiation. Secondly, a non-solvent induced phase separation method was applied for obtaining physical roughness on textiles. For the method, hydrophobic poly(vinylidene fluoride) (PVDF) and inorganic nanoparticles were selected. The effects of coagulating medium and temperature on microstructural morphology and surface hydrophobictity of the textiles were investigated. Superhydrophobic fabrics exhibiting water contact angle higher than 150° could be obtained by coating the fabrics with hybrid solutions of PVDF and ZnO nanoparticles followed by coagulation in ethanol as non-solvent. Moreover, antibacterial properties could be simultaneously obtained by utilizing photocatalytic effect of ZnO nanoparticles.
 

Speaker
Biography:

Adam Quintana served as Technological Researcher at Sandia National Laboratories in Albuquerque, New Mexico, where he developed the theoretical and numerical techniques to spatially predict polymeric oxidation. Currently, he is pursuing his PhD at the University of New Mexico, where he is studying the phase separation and dynamics of biological polymers. His expertise lies in utilizing transport and thermodynamic relationships to quantify non-linear physical systems.
 

Abstract:

Organic materials are generally susceptible to oxidation from ambient atmospheric exposure, and the extent of oxidation can be correlated to variance in the intrinsic material properties usually leading to brittleness. Oxygen gas permeation into a polymer is governed by diffusion with a reductive term derived from a free-radical mechanism of polymer oxidation. Experimental quantification of the constants governing oxygen transport and reaction allows for the numerical prediction of oxidative ingress and empirical derivations of the variance of these constants with oxidation extent allows for the prediction of heterogeneous degradation that agrees with phenomenological observations. This talk will show the numerical predictions of temporal oxidative ingress in multiple dimensions with the use of contemporary non-linear partial differential equation solving techniques.