Sevinc Ilkar Erdagi
Kocaeli University, Turkey
Title: Synthesis of Diosgenin Containing m-PEG-PCL Nanoparticles: Anticancer, Antimicrobial and Drug Delivery Studies
Biography
Biography: Sevinc Ilkar Erdagi
Abstract
Diosgenin is a steroidal saponin from a therapeutic herb. Natural products have always played a highly significant and potential role in the drug discovery. Here we developed a nanoparticle platform based on poly(ethylene glycol)-poly(caprolactone)–diosgenin (mPEG-PCL–DGN) conjugates for co-delivery of anticancer drugs. Firstly, to improve the solubility and bioavailability of DGN, the amphiphilic conjugates mPEG-PCL-DGN were made by linking DGN with PCL and mPEG. Then they self- assemblied nanoparticles to deliver another anticancer drug imatinib mesylate (ITB) by a simple nanoprecipitation method. The obtained nanoparticles possessed the appropriate size, high drug loading efficiency of diosgenin and ITB.
In this study, polymer–drug conjugates mPEG–PCL-DGN was synthesized based on PCL, mPEG, and diosgenin, in which diosgenin, PCL and mPEG was used as the hydrophobic and the hydrophilic segment, respectively. Then the mPEG–DGN self-assembled into a polymeric nanoparticle with linear PCL, mPEG, and diosgenin (Scheme 1). The nanoparticles were developed as an important strategy for drug delivery due to their capabilities of enhancing drug solubility.