Byung Gil Min has completed his PhD from Seoul National University and Post-doctoral studies from IBM Almaden Research Center in California, USA. Currently, he is working as a Professor of Kumoh National Institute of Technology located at Gumi in South Korea.
Antibacterial fabrics for use in medical textiles have been provided as useful weapon in the on-going fight against hospitalacquired infections. Generally, metal oxide nanoparticles (NPs) such as TiO2, ZnO and CuO have been applied on to cotton or synthetic fabrics. Recently, sonochemical coating technology has been introduced for the purpose of developing antibacterial fabrics. The method showed high efficiency for a wide variety of NPs to be coated on various textile substrates. This study aims to deposit copper nanoparticles (Cu-NPs) on PET fabrics using ultrasound irradiation. The structure of CuNPs/PET-fabric composites was investigated by FE-SEM (Field Emission Scanning Electron Microscopy). The adhesion of Cu-NPs to the fibers is discussed with washing tests. The excellent antibacterial activity of the Cu-NPs/PET-fabric composite is expected and would be reported in successive work. Cu nanoparticles could be successfully deposited on PET fabrics through sonochemical coating technology using probe-type ultrasound irradiation. The deposition state of Cu-NPs on the fabrics was observed to be uniform by FE-SEM. The adhesion of Cu-NPs to the fabrics was evaluated as stable enough to provide performance of antibacterial activity after five times of washing according to a standard washing condition.
Marlus Chorilli has a BSc degree in Pharmacy-Biochemistry (2002), MSc (2004) and PhD (2007) degrees in Pharmaceutical Sciences from São Paulo State University. He is presently working as Assistant Professor at the School of Pharmaceutical Sciences of Araraquara—São Paulo State University, teaching Pharmacotechniques and Pharmaceutical Technology. He is Leader of the research group “Research and Development of Nanotechnology-based Drug Release Systems” (CNPq—Brazil). He also acts as reviewer of journals in the field of Pharmaceutical Sciences and as scientific adviser of Brazilian and international research funding agencies (CNPq—Brazil, FAPESP-Brazil and FONDECY-Chile).
This study aimed to develop an in-situ gelling nanostructured liquid crystalline system composed of an oil-water-nonionic surfactant-nonionc triblock copolymer mixture for intravaginal administration. Oleic acid and cholesterol (oily phase), water (aqueous phase), Poloxamer 407 (nonionic triclock copolymer), ethoxylated propoxylated cetyl alcohol (nonionic surfactant), were used as components of the systems. After examining the phase behavior of the mixtures, we chose an isotropic system for further studies due to its greater stability and transparency. Different amounts of artificial vaginal mucus (30, 50, 100 % w/w) were added to the chosen formulation in order to mimic the possible interactions between them into the vaginal cavity. The physico-chemical properties of the obtained systems were evaluated by polarized light microscopy, small angle X-ray scattering (SAXS), rheology, texture profile and mucoadhesion analyses. Polarized light microscopy, SAXS confirmed the transition from a microemulsion to liquid crystalline mesophases after adding artificial vaginal mucus. Liquid crystalline mesophases presented a highly ordered microstructure that provides a controlled release of drugs. In addition, rheological, texture profile and mucoadhesive analysis indicated that the lyotropic liquid crystals could enhance time of treatment due to its greater viscosity and interactions with the components of the mucus. The results obtained suggest that triblock copolymerbased liquid crystalline systems have potential for intravaginal drug delivery.