4^th International Conference on Polymer Chemistry June 25-27, 2018 Stockholm, Sweden

Biography:

Boris Minaev has completed his PhD at the age of 29 years from Tomsk State University and moved later to Ukraine. He is the head of chemistry and nano-material science dept. of Cherkasy National University and professor emeritus at KTH. He has published more than 540 papers in reputed journals and has been serving as an editorial board member of repute. 

Abstract:

The general concept of spin-dependent ethylene polymerization by iron, cobalt, nickel and by chromium catalysts is developed. The role of the triplet excited state of the monomer in combination with the high spin state of the catalyst is stressed in the process of ethylene activation. The main rate-determining step in ethylene polymerization is the monomer insertion into the metal-alkyl bond; this is bond making process accompanied by bond cleavage. Catalysis of such simultaneous rearrangements can be treated by a general scheme of spin-uncoupling. The applicability of the spin-catalysis concept to the Brookhart-Gibson catalytic scheme is described by main example of the bis(imino)pyridine Fe(II) complexes. The role of the axial-equatorial isomerization in spin-catalysis of Brookhart-Gibson type is explained in connection with the main mechanistic problem of ethylene catalytic polymerization – competition between chain propagation and β-hydrogen atom transfer (BHAT) termination. Taking into account the low-steric bulk model of the bis(imino)pyridine Fe(II) complexes (without bulky substituents in all ortho-positions of aryl rings on imino-nitrogen) the spin-orbit coupling (SOC) matrix elements are calculated at the minimum energy crossing point between triplet and singlet state during the reaction isomerization path. Calculations of SOC matrix element are performed with various approximations in order to illustrate the main qualitative spin-selection rules which govern the singlet-triplet intersystem crossing (ISC) process. Account of main prominent features of electronic orbital configurations and their abrupt change upon T→S transition in the course of isomerization made it possible to obtain reliable conclusion on competitive and spin-selective ISC process in Brookhart-Gibson catalysis. A special accent is made for clear explanation for chemists of this complicated quantum physical mechanism never used before in such polymerization. It is shown for the first time that the triplet-singlet ISC is crucial for enhancement of chain termination process via “equatorial-axial” isomerization at the alkyl-ethylene π-complex stage followed by β-hydrogen atom transfer in catalysis by. Brookhart-Gibson type iron complexes. A similar analysis is applied for cyclopentadienyl complex of chromium(III) catalyst. External magnetic field effect on BHAT and chain termination yield in ethylene polymerization is predicted on the ground of strong spin selectivity in the ISC process.

Biography:

Karin Larsson is a Professor in Inorganic Chemistry at the Department of Materials Chemistry, Uppsala University, Sweden. She received a PhD in Chemistry in 1988. The research was directed towards investigation of molecular dynamic processes in solid hydrates by using solid state NMR spectroscopy. The scientific focus is on interpretation, understanding and prediction of the following processes/properties for both solid/gas interfaces, as well as for solid/liquid interfaces; i) CVD growth, iii) interfacial processes for renewable energy applications , and iv) interfacial processes for e.g. bone regeneration (incl. biofunctionalisation of surfaces). 

Abstract:

Avascular necrosis is a disease of cell death in joints, jaw, and hips due to lack of blood supply induced by burnt, inflammation or trauma, etc. The mainstream curing these days are i) arterial infusion by partial drug delivery, and ii) the replacement of the whole joints by using artificial materials. The first method can only be applied at an early stage of the disease, and the curing results. So for more severe situations, the medical implants will become the only choice. With the need for an improved stability and biocompatibility of the medical implant materials, diamond has recently become interesting as a promising material. The combination of chemical inertness and biocompatibility makes diamond a good material for e.g. biological applications.  In order to promote localized cell adhesion and vascularization onto the diamond-covered medical implants, the prerequisite for pre-adhesion of growth factors onto the diamond surfaces is of largest interest to study more in detail. It is highly necessary that these investigations are performed on an atomic level. Therefore, theoretical simulations is a necessary complementary tool to i) aid in the analysis of experimental observations, and ii) to make recommendations for corresponding experimental studies.With the purpose to tailor-make the medical implant surface by utilizing diamond’s unique properties, the present study has investigated the interaction between diamond and various biomolecules (BMP2, RGD, heparin, fibronectin, VEGF, angiopoietin). The combined effect of various surface plane and termination type (H, O, OH, and NH₂) has been of a special interest to study. Three different groupings where obtained with regard to adhesion strength. And all of these three groups showed different dependencies of the surface termination type. For all of these different scenarios, strong bond formations were observed. Evaluation of the methods used showed that the calculated trends in adhesion energy are highly reliable.

Biography:

Eri Yoshida has completed her Ph.D. in polymer engineering from Tokyo Institute of Technology.  She joined Kyoto Institute of Technology as an assistant professor.  She was also a visiting scientist at the University of North Carolina at Chapel Hill.  She is an associate professor at Toyohashi University of Technology.  She has published more than 100 papers in international journals and has 24 patents.  She has been serving as an editorial board member of some international journals.

Abstract:

Worm-like organisms are often observed as baculiform cells and tubular organelles.Worm-like vesicles are regarded as artificial models of biomembrane for these cells and organisms and are expected as new carriers for drug and gene delivery.  This paper describes the synthesis of worm-like vesicles consisting of amphiphilic poly(methacrylic acid)-block-poly(methyl methacrylate-random-methacrylic acid), PMA-b-P(MMA-r-MA), through the photo nitroxide-mediated controlled/living radical polymerization (photo NMP)-induced self-assembly.  The mechanism of the formation and stimuli-responsive behavior of the worm-like vesicles are also described.  The worm-like vesicles were prepared by the photo NMP-induced self-assembly of PMA-b-P(MMA-r-MA) using 4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxyl in an aqueous methanol solution.  It was found that the polymerization had the living nature based on the linear correlation between the molecular weight and monomer conversion.  The copolymer during the early stage of the polymerization produced cup-like vesicles with the thin and flexible bilayer including some holes in the surface.  As the hydrophobic P(MMA-r-MA) block chain was extended by the polymerization progress, the cup-like vesicles were transformed into spherical vesicles, followed by worm-like vesicles due to the incorporation of the spherical vesicles.  The worm-like vesicles had the major axis of 3.41 mm and minor axis of 0.437 mm on average.  The vesicles were sensitive to temperature and transformed into spherical or shorter worm-like vesicles and finally into a fused plane by a temperature increase.  The worm-like vesicles were restored by decreasing the temperature through branched tubules.The worm-like vesicles were also sensitive to pH and salt concentration and more stable than spherical vesicles consisting of PMA-b-P(MMA-r-MA).

Biography:

Abstract:

Biography:

Dr. Sanboh Lee has been endowed Tsing Hua Chair Professor in the Department of Materials Science and Engineering, National Tsing Hua University. His previous affiliation was Xerox Company. He was a visiting professor at Lehigh University and National Institute of Standards and Technology. To name several of those awards, he was the recipient of 1998 Roon Foundation Award from Federation Society of Coating Technology. He served as an award committee member, TMS. He awarded Fellows of ASM in 2004 and MRS-Taiwan in 2009.  He published 250 articles in peer-reviewed journals.

Abstract:

Biography:

Jaroslav Minar completed his master studies at the age of 25 years from University of Chemistry and Technology, Prague, where he continues in his doctoral studies under supervision of Professor JiÅ™í Brožek. His fields of interests are polymer nanocomposites based on graphene oxide. He works for an industrial research company, where he focuses on a pyrolysis of a plastic waste.

Abstract:

Biography:

Dr. Oommen Varghese did his PhD in organic chemistry from Uppsala University, Sweden. After his PhD he changed his research area towards biomedical science that combines different disciplines. In 2016, he was promoted as Associate professor at Uppsala University. The focus of his research is regenerative medicine and targeted drug delivery, bridging synthetic organic chemistry and biotechnology. His research interests are in the fields of designing functional polymers and biomaterials for tissue engineering, drug delivery and nucleic acids therapeutics. He authored several peer reviewed articles and book chapters. He has also filed several patents and is a co-founder of a spin-off called ‘Uppsala Therapeutics AB’.

Abstract:

Designing injectable gels that mimic the natural extracellular matrix (ECM) has been of great interest in the field of regenerative medicine. We have previously demonstrated that hyaluronic acid (HA) hydrogel having hydrazone crosslinkages could be used for efficient delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2) and form bone in vivo within 6 weeks when injected below the rat periostium. Though rhBMP-2 is very potent for inducing bone formation, recently, extensive debate has taken place on the clinical use of rhBMP-2 since several complications in patients has been observed. This is mainly due to supraphysiological dose that is clinically used since the collagen-based BMP-2 carrier is inefficient and does not stabilize rhBMP-2 in vivo. We have devised a new strategy to engineer hydrazone crosslinked HA hydrogel such that it differentially interact with rhBMP-2 and provide different release kinetics of the bioactive protein. In order to understand the binding affinity between HA modification and the heterodimer structure of rhBMP-2, we performed computational analysis by performing molecular docking followed molecular dynamics experiments. The results of the computational analysis clearly indicated that electrostatic and Vander Waal’s interactions play a predominant role in stabilizing rhBMP-2 and control its release. To further understand the significance of protein release on bone formation, we performed in vivo bone induction experiments in a rat ectopic model. The in vitro release experiments corroborated very well with the in vivo experiments, which clearly indicate that improving BMP-2 interactions with HA has major impact in stem cell recruitment and bone induction in vivo. Such a biomaterial design strategy could also be easily adapted to deliver other growth factors for different biomedical applications.

Biography:

Magdalena Simona Fogorasi is Assoc. Prof. at the Aurel Vlaicu University of Arad, Romania with expertise in Textile Chemistry. She accomplished her PhD in the field of Textile Biotechnology.  She collaborated on several European and National Projects on Textile Finishing, particularly on Biotechnology for fibres modification and textile waste valorization.  She is a reviewer for several prominent journals and editorial board member.

 

 

 

Abstract:

Polymers are present in almost every aspect of our daily life. Textile field is one of the largest industry using fibres derived from both natural and synthetic polymers. In the last decades, the textile industry has endorsed significant growth in new fibers, especially synthetic fibers with improved and special properties, most of them designed for niche products.

For this century the new fibers will be created in association with other industrial fields, being notably influenced by the information technology and advances in nano- and biotechnology.

Application of biotechnology to polymer/textile materials envisages emerging areas like improvement and adjustment of properties in fibres and development of new fibres and polymers.

The presentation is addressed to the potential of biotechnology to improve and modify properties in polymers, with special reference to biochemical processing of fibres acquired from natural polymers. The benefits of biotechnologies – as convenient alternatives to traditional chemical procedures - are exploited in processing of natural and synthetic polymers. Natural fibers like cotton and wool, possess a non-even and nonhomogeneous surface. Their specific function can be ascribed to their complicated morphological structure. Conventionally, raw fibres are subjected to several chemical processes to obtain desired features proper for use.

The paper offer an authentic approach in highlighting the interface between biotechnology and polymers (textile fibres) dealing with reaction mechanisms, modified fibres properties and environmental issues.

 

Biography:

Adam Quintana was a technological researcher at Sandia National Laboratories in Albuquerque, New Mexico where he developed the theoretical and numerical techniques to spatially predict polymeric oxidation. He is now a Ph.D. candidate at the University of New Mexico where he is studying the phase separation and dynamics of biological polymers. His expertise lies in utilizing transport and thermodynamic relationships to quantify non-linear physical systems. 

Abstract:

Organic materials are generally susceptible to oxidation from ambient atmospheric exposure, and the extent of oxidation can be correlated to variance in the intrinsic material properties usually leading to brittleness. Oxygen gas permeation into a polymer is governed by diffusion with a reductive term derived from a free-radical mechanism of polymer oxidation. Experimental quantification of the constants governing oxygen transport and reaction allows for the numerical prediction of oxidative ingress, and empirical derivations of the variance of these constants with oxidation extent allows for the prediction of heterogeneous degradation that agrees with phenomenological observations. This talk will showcase the numerical predictions of temporal oxidative ingress in multiple dimensions with the use of contemporary non-linear partial differential equation solving techniques. 

Biography:

Dr. K. Balaji, has completed his PhD at the age of 29 years from Ann University. He is working as a Assistant Professor in PSG Institute of Technology and Applied Research, Coimbatore, India. He has published 8 papers in reputed journals and has been serving as an editorial board member of reputed internationl journals. Attended various international conference in USA, Germany, Japan, etc.,

Abstract:

Biography:

Johanna completed her bachelor and master studies at the Institute of Applied Synthetic Chemistry of the Technical University of Vienna, where she successfully did her first publications. She did her Master Thesis in cooperation with the company “Semperit” with the topic of “Process Enhancement of Rubber Compounding”. In 2016, Johanna joined the Polymer Composite and Engineering group at the University of Vienna for her PhD Thesis working on “High-Performance BIOpolymer-Compounds”. Her PhD-project is based on a cooperation with the company Franz S. Huemer Holding, and the research institute Laboratory for Polymer Engineering.
 

Abstract:

“BigBags”, made of stretched standard polymer tapes (e.g. iPP, PE-HD, PET, and PA), are suitable packaging materials with the required mechanical properties for heavy loads, e.g. fertilizers in agricultural applications. Based on environmental aspects, synthetic highly-stretchable polymer tapes should be replaced by resource-saving Biopolymers to avoid polymer-waste. Until today no Biopolymer-compounds with high-strength properties are known and basic know-how about correlations between stretching parameters and materials properties is very scarce, especially for Biopolymers.

Compounds of starch and Biopolyesters are promising materials for the production of biodegradable products, because of their availability, renewability and biodegradability. However, compared to stretchable films made of synthetic polymers elongations at break of starches are lower by a factor of 100. Plasticizers are used to increase flexibility and stretchability of starch, which is termed “thermoplastic starch” (TPS). The most common plasticizer is glycerol, which reduces the intermolecular bonding forces by increasing the inter(macro)molecular distance.

In this study the influence of different starch pretreatments (e.g. acid degradation) and starch sources (potatoe, maize, …) to the strechability and mechanical properties were investigated. The goal was to develop high-strength TPS-Biopolyester-compounds, which allow for a high stretchability and stiffness as required in BigBag-applications.

Furthermore, correlations between material properties and stretching parameters of Biopolymer-compounds were evaluated. It was found that parameters, such as sample geometry, temperature, degree, as well as velocity of stretching have an influence on mechanical properties. Thick and narrow samples, higher temperatures and lower velocities of stretching result in better mechanical properties. Ultimately, results indicate that the degree of stretching should be lower than 100%.

Biography:

Sevinc Ilkar Erdagi continues her PhD in Kocaeli University, Turkey under supervisior of Prof. Dr. Ufuk Yildiz. She is research assistant in Kocaeli Univeristy for seven years. She studies organic chemistry and polymer chemistry especially in steroid chemistry and natural products.

Abstract:

Diosgenin is a steroidal saponin from a therapeutic herb. Natural products have always played a highly significant and potential role in the drug discovery. Here we developed a nanoparticle platform based on poly(ethylene glycol)-poly(caprolactone)–diosgenin (mPEG-PCL–DGN) conjugates for co-delivery of anticancer drugs. Firstly, to improve the solubility and bioavailability of DGN, the amphiphilic  conjugates mPEG-PCL-DGN were made by linking DGN with PCL and mPEG. Then they self- assemblied nanoparticles to deliver another anticancer drug imatinib mesylate (ITB) by a simple nanoprecipitation method. The obtained nanoparticles possessed the appropriate size, high drug loading efficiency of diosgenin and ITB.

In this study, polymer–drug conjugates mPEG–PCL-DGN was synthesized based on PCL, mPEG, and diosgenin, in which diosgenin, PCL and mPEG was used as the hydrophobic and the  hydrophilic segment, respectively. Then the mPEG–DGN self-assembled into a polymeric nanoparticle with linear PCL, mPEG, and diosgenin (Scheme 1). The nanoparticles were developed as an important strategy for drug delivery due to their capabilities of enhancing drug solubility.

Biography:

Abstract:

The requirements for quality drinking and industrial water are increasing and water resources are depleting. Moreover large amount of wastewater is being generated and dumped into water bodies without treatment. These have made improvement in water treatment efficiency and its reuse, an important agenda. Membrane technology for wastewater treatment is an advanced process and has become increasingly popular in past few decades. There are many traditional methods for tertiary treatment such as chemical coagulation, adsorption, etc. However recent developments in membrane technology field have led to manufacturing of better quality membranes at reduced costs. This along with the high costs of conventional treatment processes, high separation efficiency and relative simplicity of the membrane treatment process has made it an economically viable option for municipal and industrial purposes. Ultra filtration polymeric membranes can be used for waste water treatment and drinking water applications. The proposed work focuses on preparation of one such UF membrane- Polyvinylidene fluoride (PVDF) doped with LiBr for waste water treatment. Majorly all polymeric membranes are hydrophobic in nature. This property leads to repulsion of water and hence solute particles occupy the pores, decreasing the lifetime of a membrane. Thus modification of membrane through addition of small amount of salt such as LiBr helped us attain certain characteristics of membrane, which can be then used for many applications such as waste water treatment. The membrane characteristics were investigated through measuring its various properties such as porosity, contact angle and wettability to find out the hydrophilic nature of the membrane and morphology (surface as well as structure). Pure water flux, salt rejection and permeability of membrane were determined by permeation experiments. A comparative study of membrane characteristics of simple and modified membranes with various concentration of LiBr helped us know its affectivity.

Biography:

Anshul kestwal currently pursuing B.tech in Chemical Engineering (Specialization in refining & Petrochemicals) from University Of Petroleum & Energy Studies Dehradun , Uttrakhand India and this is the first research paper writing.

Abstract:

Multi - purpose camoflauge suit using nanotechnology and thermosensitive polymer : The idea is to create such a suit that is almost invisible in certain environment and can be primarily used for army and spying purposes, this kind of technology was once considered highly futuristic and fictitious but since the polymer science has grown to a vast extent and now colour changing polymers are also available, therefore here we tend to use such a polymer which changes its colour with temprature with almost all other properties remaining the same. The suit will be made from such a polymer with nanochips embedded at suitable sites within the suit at almost every sqaure inch, the nanochips will be programed such that to extract the information of surrounding through other sensing devices and thus produce  suitable temprature zones resulting in total camoflauge .

Biography:

Tao Tang has completed his PhD in 1991 from Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences. He is a full professor of polymer chemistry in CIAC. He has published more than 230 papers in reputed journals.    
 

Abstract:

Biography:

Hanying Zhao is a professor in the College of Chemistry, Nankai University. He received his Ph. D. in Macromolecular Chemistry and Physics from Changchun Institute of Applied Chemistry, Chinese Academy of Sciences in 1997 with Prof. Baotong Huang, and carried out post-doctoral researches at Fudan University, Institute of Polymer Research Dresden, University of Florida and Clarkson University. His research interests are in the synthesis and self-assembly of polymers with different topological structures, polymer brushes, polymer-protein hybrids and polymer nanocomposites.

Abstract:

Biography:

Dongmei Cui has completed her PhD from Changchun Institute of Applied Chemistry, Chinese Academy of Sciences and postdoctoral studies from Riken (Japan). She is the full professor and holder of “A hundred talent scientists programm” of Chinese Academy of Sciences, a group leader of Rare-Earth Organometallic Chemistry and Catalysis. She has published more than 180 papers in reputed journals and claimed more than 40 patents.

Abstract:

The sequence precisely controlled polymerization of dienes and styrene by using rare-earth metal catalysts will be reported. The polymerization of styrene with extremely high syndioselectivity and catalytic activity have been achieved by using with almost the whole period of rare-earth metals based catalysts. The DFT simulation reveals that the ligand contributes to lower the LUMO energy of the active species, thus the activation energy is reduced and the catalytic activity increases. Based on this by changing the central metal size, the random, block, gradient and tapert microstructured butadiene-styrene copolymers were obtained. The electron donating side arm of the ligand, on the other hand, may increase the electron density of the active species, therefore, increase its durability to the polar monomers such as methoxyl and methysilyl styrenes, leading to, for the first time, highly active and syndioselective polymerization of these polar styrenes, to give functional polystyrenes. In addition, the copolymerization of ethylene and styrene with polar styrenes are achieved. The position of the substituted polar group influence the coordination mode of the polar styrene to the active metal center, and further the reaction ratios of the polar and nonpolar styrenes, to afford different alternating ethylene/polar-styrene copolymers and styrene-polar styrene copolymers with different monomer sequence distributions.

Biography:

Professor Qing Chang graduated from the Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences, and obtained his MD. He is currently a professor at the School of Environmental and Municipal Engineering at Lanzhou Jiaotong University of China. He has been active over 40 years in his field and has been an investigator as the leader to propose, carryout, manage and finish various research project. He has authored over 150 papers published in peer- reviewed journals and four books published by Chinese publishers and one book by Elsevier Inc.He was awarded three prizes by Chinese government for his contribution to science and technology.

Abstract:

Flocculation is one of the most important methods of water treatment. The targets of flocculant’s action are the hydrophobic colloids and suspended particles which consist of insoluble substances. In recent years it was found that some macromolecule flocculants are able to trap soluble heavy metal ions in aqueous solution if some strong ligands for heavy metals are linked to their molecules by chemical bonds, thus the macromolecule flocculants with the function of trapping heavy metals have been prepared. It was reported before by our research group that we developed three methods for preparation of such macromolecule flocculants: (1)Polyethyleneimine-sodium xanthogenate (PEX) was prepared by grafting a xanthogenate group to polyethyleneimine under the alkaline condition; (2) Starch-graft-polyacrylamide-co-sodium xanthate (CSAX) was synthesized by grafting copolymerization reaction of corn starch, acrylamide (AM) and sodium xanthate using epichlorohydrin (EPI) as cross-linking reagent and ceric ammonium nitrate (CAN) as initiator; (3) Mercaptoacetyl chitosan (MAC) was prepared by reacting chitosan with mercaptoacetic acid in the presence of 1-ethyl-3-3 (dimethylamino-propyl) carbodiimide hydrochloride (EDC·HCl) as the activating agent.

The experiments proved that this kind of flocculant has many remarkable advantages, for example, high removal efficiency, fast sedimentation velocity, good separation effect, and more applicability to the treatment of the water which contains both turbidity and heavy metals, showing good prospect of both research and usage. This research increased the kinds of target of flocculant’s action and extended the research area of flocculation in water treatment.

Biography:

Dr. Shahid Iqbal received his Ph.D. degree at School of Chemistry and Chemical Engineering, National Engineering Laboratory for VOCs Pollution Control Material & Technology, University of Chinese Academy of Sciences, Beijing, China in 2017. Currently, he is a post-doctoral researcher at International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, School of Energy & Power Engineering, Xi’an Jiaotong University. He has published more than 17 peer-reviewed papers in reputed journals. His research interest is focused on the controlled synthesis and thickness-dependent catalytic properties of few-layered transition metal dichalcogenides (TMDs) for efficient photocatalytic hydrogen evolution and CO₂ conversion.

Abstract:

In a typical photocatalytic reaction, efficient solar light harvesting and charge generation, as well as effective charge transport, are key factors that determine the efficiency of the photocatalytic system for H₂ production. Atomically layered heterostructures have attracted significant research interest due to their unique layer-dependent catalysis and electronic properties. Previous studies have reported that the catalytic properties of MoS₂ layered materials are highly dependent on the number of layers, and the difficulty of controlling the number of layers over a substrate has been a bottleneck for widespread use. Therefore, developing a simple, facile and environmentally friendly method to fabricate van der Waals heterostructures (vdWHs) with precisely controlled MoS₂ layers for achieving highly efficient H₂ generation is still a challenge. Here we report for the first time that the H₂ bubbles generated by photocatalytic water splitting are effective in the layer-by-layer exfoliation of MoS₂ nanocrystals (NCs) into few layers (Figure 1). The as obtained few layers can be in situ assembled with CdS nanosheets (NSs) into vdWHs of few-layered MoS₂/CdS NSs which, in turn, are effective in charge separation and transfer, leading to enhanced photocatalytic H₂ production activity. The few-layered MoS₂/CdS vdWHs exhibited a H₂ evolution rate of 140 mmol g_(CdS)^-1 h^-1 and achieved an apparent quantum yield of 66% at 420 nm. This study provides a new strategy for the design of noble-metal-free few-layered MoS₂/CdS vdWH systems for photocatalytic H₂ generation. We believe that this bubble exfoliation strategy can be extended to a range of other layered transition metal dichalcogenide compounds.

Biography:

Samira Jafari received her master’s degree in analytical chemistry from the University of Tabriz and is currently pursuing her doctorate of chemistry in the analytical area at Imam Khomeini International University.  In addition to her master’s degree, Samira is well travelled in her schooling and as such has acquired a wide range of different chemistry styles.  With this experience, she gleaned and culminated a wide scope of techniques to develop a novel method for targeting various cancers efficiently with relatively low costs as compared to customized patient medicines.  With a generic customized cancer drug delivery system as described in her work, a new field of focus is presented that can make large strides in the fight against breast cancer.

Abstract:

Polyurethanes have great variety of physical and chemical properties due to their different building blocks in their structure which make them possible for different biomedical and pharmaceutical applications. The most important application of these polymers is as a biocompatible, smart and controllable drug carrier which direct the anticancer drugs sufficiently to the cancerous cells for solving the problem of inadequate drug cargo with less side effects to the cancerous tissue cells. In this article, a kind of new drug delivery system is introduced which is smart controllable (pH-sensitive) multifunctional magnetic polyurethane(SCMMP) nano composite composed of isocyanate as a main chain and Cyclodextrin as a chain extender with the magnetic nano particles in their structure. Then Consequently, The bulk structure, size and morphology and magnetic characteristic of the synthetic nano-composite was characterized through different accepted analytical techniques such as FT-IR, TGA, XRD, TEM, SEM, DLS  and VSM respectively. The SCMMP was used for loading tow effective currently used pharmaceutical cancer agents of Metatroxate and doxorubicin with high loading efficiency of 87% and 89% respectively. Dual drug loaded nano composite release behaviour was investigated in three different pHs of 4.5, 5.4 and 7.4. According to the concentration profile, low release percentage in the pH=7.4 for long term circulation and good stability in blood stream and high release in pH of 4.5 and 5.4 for improving vast variety of cancerous cells in physiological media were observed. Thereupon, new drug carrier system have great efficacy for cancer therapy. The MTT calorimetric method was used to track the presented nano composite eligibility as a polymer based drug delivery system.  Different cellular tests of MTT assay, DAPI staining, cellular uptake and cell cycle was done on Nan composite/DOX/MX combination versus free DOX/MX to validate it as a nano carrier. Biocompatibility of the nano carrier was done using hemolysis assay through checking on human red blood cells (HRBCs) with very fine results. According to the results, introduced system is very effectible one for delivering synchronous therapeutic agents of DOX and MX to the cancerous cells and on other hand for in vivo usage in the future.

Biography:

Dr. Min has completed his PhD from Seoul National University and postdoctoral studies from IBM Almaden Research Center in California, USA. He is a professor of Kumoh National Institute of Technology located at Gumi in South Korea.

Abstract:

Antibacterial fabrics for use in medical textiles has been provided a useful weapon in the on-going fight against hospital-acquired infections. Generally, metal oxide nanoparticles(NPs) such as TiO₂, ZnO and CuO have been applied on to cotton or synthetic fabrics. Recently sonochemical coating technology has been introduces for the purpose of developing antibacterial fabrics. The method showed high efficiency for a wide variety of NPs to be coated on various textile substrates. This study aims to deposit copper nanoparticles (Cu-NPs) on PET fabrics using ultrasound irradiation. The structure of Cu-NPs/PET-fabric composites was investigated by FE-SEM. The adhesion of Cu-NPs to the fibers is discussed with washing tests. The excellent antibacterial activity of the Cu-NPs/PET–fabric composite is expected and would be reported in successive work. Cu nanoparticles could be successfully deposited on PET fabrics through sonochemical coating technology using probe-type ultrasound irradiation. The deposition state of Cu-NPs on the fabrics were observed to be uniform by FE-SEM. The adhesion of Cu-NPs to the fabrics were evaluated as stable enough to provide performance of antibacterial activity after 5 times of washing according to a standard washing condition.

Biography:

Zlata Hrnjak-Murgić work at the University of Zagreb as full professor. She has completed hers PhD in 1996 and postdoctoral studies from Darmstat Institute. She has published more than 60 papers in reputed journals, gives 8 lecturs at the conferens, lead 6 research projects, 8 doctroals theses, member of 8 scientific conference organizing committy. She is reviewer for 20 scientific journas, for the European Commission reviewed 50 EU projects, Poland (NCBR) and Slovenian national foundations aditional 20 projects.

Abstract:

TiO₂ is an excellent photocatalyst under UV light but its high band gap limits its activity under visible light and restricts the practical application. The PEDOT conductive polymer was used to increase the photocatalytic activity of TiO₂ as conductive polymers are known to be efficient electron donor and good electron transporters upon visible-light excitation. For that reason the nanocomposite photocatalysts of conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and TiO₂ nanoparticles were prepared by in-situ synthesis for catalytic waste water treatment. The synthesis was carried out by chemical oxidation polymerization with FeCl₃ oxidant with the ratio EDOT monomer:oxidant 1:1, while the ratio of monomer and TiO₂ nanoparticles was 1:10 and 1:20. Studied photocatalysts were characterized by FTIR spectroscopy, SEM microscopy, TG analysis and by the determination of conductivity. The photocatalytic activity was assessed through degradation of Acid Blue 25 dye (AB25) under simulated Solar irradiation. Photocatalysis was monitored by measuring discoloration of AB25 using UV/Vis spectroscopy. The kinetics of photocatalytic degradation of AB25 was determined as well. The effect of photocatalytic media on catalysts efficiency was also considered due to strong interactions between catalyst and pollutant.

The results indicate the strong interactions of PEDOT polymer and AB25 because very high adsorption of dye onto PEDOT/TiO₂ nanocomposite catalysts was observed. The pH media of suspension during catalytic water treatment significantly affected those interactions and photocatalysis process.

Biography:

By in-situ chemical oxidation polymerization polypyrrole/titanium dioxide (PPy/TiO₂) nanocomposite photocatalysts were prepared for photocatalytic wastewater purification under simulated solar irradiation. To enhance TiO₂ photoactivity under visible light and to reduce economic expenses during wastewater treatment PPy conductive polymer was applied. Conductive PPy polymers with extending conjugated electron systems act as stable photosensitizers injecting electrons into the conduction band of TiO₂ (due to their π conjugated electrons). The study was aimed elucidate the stability and loss of conductivity under alkaline conditions during photocatalysis. The deprotonation, which is responsible for conductivity reduction, is discussed on the bases of salt–base transition in polypyrrole due to treatment of nanocomposite by ammonium hydroxide (NH₄OH). The stability towards the loss of conductivity by deprotonation was validated by measuring their electroconductivity and photocatalytic activity. Further, studied PPy/TiO₂ nanocomposite photocatalysts were characterized by FTIR and spectroscopy, TG analysis and SEM microscopy. Photocatalytic activity of PPy/TiO₂ nanocomposite photocatalysts was estimated by monitoring the discoloration of Reactive Red (RR45) azo dye in wastewater monitored by UV/Vis spectrophotometer at the maximum wavelength (λ_max=542 nm). The kinetics of photocatalytic degradation rate of RR45 was studied as well. The mineralization process was followed by determination of total organic carbon (TOC).

From the results it was concluded that deprotonation process significantly decreased the conductivity of PPy/TiO₂ nanocomposite photocatalysts since the conductivity of 17.6 S/cm was observed after in situ synthesis and only 7.1 x 10^-5 S/cm was notified after the deprotonation. The consequence of deprotonation was also lower photocatalytic degradation rate of RR45 dye in wastewater purification.

Abstract:

Vanja Gilja is PhD student at University of Zagreb, Faculty of Chemical Engineering and Technology, 2 months research visit at University of Auckland. She has published 4 papers in reputed journals and 3 proceedings, participated at 17 scientific conferences and held one oral presentation. She is a member of Croatian Society of Chemical Engineers.

Biography:

Anjaneyulu, k has completed his Postgraduation in Organic chemistry from Kakatiya University, Presently he is working with Dr. Debashis Chakarborty in Chemistry Department, Indian Instutite of Technology- Madras, INDIA. As a Senior research fellow, Working on Synthesis of Biodegradabule polymers, and its applications in Drug delivary, and Developeing of Green methods, for Ring-Opening polymerization methods.

Abstract:

Recent work has been directed to the design of metal- free Lewis pair catalysts for ringopening alternating copolymerization  (ROAP) reactions to enhance both activity and selectivity. While the simplest type of organic bases/Lewis bases (for example: PPN+Cl-, DMAP, DBU and TBD) are able to copolymerize anhydride-epoxide in a non-living and nonquantitative manner, the introduction of Lewis acids radically changes this behaviour. In this study, various Lewis acids (B(C2H5)3, Al(CH)3, Et2Zn and nBu2Mg), in combination with various Lewis bases (PPN+Cl-, DMAP, DBU and TBD), were tested as Lewis pair catalysts for anhydride- epoxide ring-opening copolymerization (ROCOP) studies. Based on the observed results, the B(C2H5)3/PPNCl pair stood out as the most active and effective Lewis pair for the perfectly alternating and regioselective controlled ROCOP of various epoxides (cyclohexene oxide, CHO; tert- butyl glycidyl ether, tBGE and 2-benzyloxirane, BO) with  pthalic anhydride (PA). Medium to high molecular weight linear poly(ester-co- ether)s (Mn up to 57.5 kg mol-1) were achieved, and most of them exhibit narrow molecular weight distributions (Mw/Mn as low as 1.02). However, in the presence of strong Lewis acids (Al(CH)3, Et2Zn and nBu2Mg) and neutral Lewis bases (DMAP/DBU/TBD) this broad applicability is offset by a lack of control over the polymerizations, including side reactions as a consequence of it’s strong acidity/alkalinity. Hence, the ideally suitable acidity/alkalinity and matched size of the Lewis pair are considered crucial for the effective copolymerization of PA and epoxides. In addition, from PA/tBGE copolymers, hydroxyl-functionalized poly (ester-co-glycerol)’s were   successfully  synthesized   by  deprotection   of  the  t-butyl  groups.

Biography:

Yulun Tao, Associate Professor is in Department of Materials Science and Engineering, Anhui University of Science and Technology. He grew up in China and received his Bachelor's degree from the Anhui normal University in 2002. After he obtained his Ph.D. degree from the Anhui University during 2008-2012, he acted as a creative scientist appointed Assistant Professor in Anhui University of Science and Technology. The main research is the polymer semiconductors especially in insoluble polyaniline, polypryyol and PPV crystalline materials, self-assembly, and study optical and electrical properties.
 

Abstract:

It is interesting that ordered 3D layered crystals of polyaniline formed, after these sphere-like nanoparticles were dispersed into nonpolar cyclohexane. During the initial stages, their irregular polymer chains could easily swell and stretch, aggregate and crystallize into coded nanosheets with highly ordered polymer chains, uniform shape and morphology by intermolecular noncovalent bonding. These nanosheets then self-assembled into 3D π–π stacked crystal structures along the optimal dynamic path. In this experiment, p–p interactions provide an excellent tool for assessing the efficiency of particular synthons of 3D π–π stacked structures with high conductivity.

Biography:

Marlus Chorilli has a B.Sc. degree in Pharmacy-Biochemistry (2002) and M.Sc. (2004) and Ph.D. (2007) degrees in Pharmaceutical Sciences from São Paulo State University. He is presently Assistant Professor at the School of Pharmaceutical Sciences of Araraquara—São Paulo State University, teaching Pharmacotechniques and Pharmaceutical Technology. He is leader of the research group “Research and Development of Nanotechnology-based Drug Release Systems” (CNPq—Brazil). He also acts as reviewer of journals in the field of Pharmaceutical Sciences and as scientific adviser of Brazilian and international research funding agencies (CNPq—Brazil, FAPESP-Brazil and FONDECY-Chile)

Abstract:

This study aimed to develop a in-situ gelling nanostructured liquid crystalline system composed of an oil-water-nonionic surfactant-nonionc triblock copolymer mixture for intravaginal administration. Oleic acid and cholesterol (oily phase), water (aqueous phase), Poloxamer 407 (nonionic triclock copolymer), ethoxylated propoxylated cetyl alcohol (nonionic surfactant), and were used as components of the systems. After examining the phase behavior of the mixtures, we chose an isotropic system for further studies due to its greater stability and transparency. Different amounts of artificial vaginal mucus (30, 50, 100 % w/w) were added to the chosen formulation in order to mimic the possible interactions between them into the vaginal cavity. The physico-chemical properties of the obtained systems were evaluated by Polarized light microscopy, Small Angle X- Ray Scattering (SAXS), rheology, texture profile and mucoadhesion analyses. Polarized light microscopy, SAXS confirmed the transition from a microemulsion to liquid crystalline mesophases after adding artificial vaginal mucus. Liquid crystalline mesophases present a highly ordered microstructure that provide a controlled release of drugs. In addition, rheological, texture profile and mucoadhesive analysis indicated that the lyotropic liquid crystals could enhance time of treatment due to its greater viscosity and interactions with the components of the mucus. The results obtained suggest that triblock copolymer-based liquid crystalline systems have potential for intravaginal drug delivery.

 

Biography:

Marlus Chorilli has a B.Sc. degree in Pharmacy-Biochemistry (2002) and M.Sc. (2004) and Ph.D. (2007) degrees in Pharmaceutical Sciences from São Paulo State University. He is presently Assistant Professor at the School of Pharmaceutical Sciences of Araraquara—São Paulo State University, teaching Pharmacotechniques and Pharmaceutical Technology. He is leader of the research group “Research and Development of Nanotechnology-based Drug Release Systems” (CNPq—Brazil). He also acts as reviewer of journals in the field of Pharmaceutical Sciences and as scientific adviser of Brazilian and international research funding agencies (CNPq—Brazil, FAPESP-Brazil and FONDECY-Chile).

Abstract:

The vaginal mucosa is accessible, has an excellent blood supply, and shows the absence of the first-pass effect, which makes it a very attractive drug delivery route. However, this route has limitations, mainly due to the difficulty of adherence of the formulation in the vaginal mucosa. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can increase drug permeation through the mucosa and thereby improve drug delivery. The presence of mucoadhesive polymers in the aqueous phase of the platforms, such as polyethyleneimine and chitosan, can further increase the permanence of the formulation at the site of action. This study aimed at developing and characterizing the mechanical, rheological, and mucoadhesive properties of four liquid crystalline precursor systems (LCPSs) composed of four different aqueous phases (i) water (FW),(ii)chitosan (FC), (iii) polyethyleneimine (FP), or (iv) both polymers (FPC); oleic acid was used as the oil phase, and ethoxylated and propoxylated cetyl alcohol was used as the surfactant. Polarized light microscopy and small-angle X-ray scattering indicated that all LCPSs formed liquid crystalline states after incorporation of vaginal mucus. Rheological, texture, and mucoadhesive assays showed that FPC had the most suitable characteristics for vaginal application. In vitro release study showed that FPC could act as a controlled drug delivery system. Finally, based on in vitro cytotoxicity data, FPC is a safe buccal drug delivery system for the treatment of several vaginal diseases.

Biography:

Payam Hayati has completed his PhD at the age of 34 years from Sistan&Baluchestan University  in Iran and has two master licence in inorganic chemistry and exprimental chemistry from islamic azad universtry and university of autonuma from Iran and Spain, respectively. He has published more than 10 papers in reputed journals, has been published 3 books and was as researcher in millan university for 6 month.

Abstract:

Novel 2D coordination polymer compounds with different nitrogen and oxygen donor ligands coordinated to different metals (cadmium and lead) have been synthesized by the branched tube method (heat gradient applied to a solution of the reagents). This method allows the formation of single crystals suitable for their analysis by single crystal X-ray diffraction (SXRD). Also, the same coordination polymer compounds were synthesized following a sonochemical process involving ultrasonic irradiation, which allow the micro/nano-structuration of the studied systems. Additionally, the role of different experimental parameters (temperature, reaction time and ultrasound irradiation power) and their effect on the size and morphology of the micro/nano-structured coordination polymer compounds have been investigated [1-4] and the results shown here. 

Biography:

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Biography:

Byung Gil Min has completed his PhD from Seoul National University and Post-doctoral studies from IBM Almaden Research Center in California, USA. He is a Professor of Kumoh National Institute of Technology located at Gumi in South Korea.

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Biography:

Sevinc Ilkar Erdagi is pursuing her PhD in Kocaeli University, Turkey under supervision of Prof. Dr. Ufuk Yildiz. She is a Research Assistant in Kocaeli University for seven years. She studies Organic Chemistry and Polymer Chemistry especially in steroid chemistry and natural products.

Abstract:

Diosgenin is a steroidal saponin from a therapeutic herb. Natural products have always played a highly significant and potential role in the drug discovery. Here, we developed a nanoparticle platform based on poly(ethylene glycol)poly(caprolactone)–diosgenin (mPEG-PCL–DGN) conjugates for co-delivery of anticancer drugs. Firstly, to improve the solubility and bioavailability of DGN, the amphiphilic conjugates mPEG-PCL-DGN were made by linking DGN with PCL and mPEG. Then they self-assembled nanoparticles to deliver another anticancer drug imatinib mesylate (ITB) by a simple nanoprecipitation method. The obtained nanoparticles possessed the appropriate size, high drug loading efficiency of diosgenin and ITB. In this study, polymer–drug conjugates mPEG–PCLDGN was synthesized based on PCL, mPEG, and diosgenin, in which diosgenin, PCL and mPEG were used as the hydrophobic and the hydrophilic segment, respectively. Then the mPEG– DGN self-assembled into a polymeric nanoparticle with linear PCL, mPEG, and diosgenin (Figure). The nanoparticles were developed as an important strategy for drug delivery due to their capabilities of enhancing drug solubility